Dr Alexander Fletcher

Position: Senior lecturer
Home page: http://alex-fletcher.staff.shef.ac.uk
Telephone: (0114) 2223846
Office: G15 Hicks building
Photo of Alexander Fletcher


MAS115 Mathematical Investigation Skills Information Home page


Interests: Mathematical biology, morphogenesis, tissue dynamics
Research group: Mathematical Biology
Publications: ArXiv, MathSciNet


Current grants, as Principal Investigator
Chaste: developing sustainable software for computational biology
Understanding self-organised tissue patterning across scales EPSRC
Current grants, as Coinvestigator
Hypothalamic development from self-organising progenitors
Past grants, as Coinvestigator
How do the atypical cadherins Fat and Dachsous integrate growth and patterning during development?


2022 - present: Senior Lecturer, SoMaS, University of Sheffield
2019 - 2022: Lecturer, SoMaS, University of Sheffield
2015 - 2019: Vice-Chancellor's Fellow, SoMaS, University of Sheffield
2011 - 2015 : Research Fellow in Computational Science, Mathematical Institute, University of Oxford
2008 - 2015 : Stipendiary Lecturer in Mathematics, St Hugh's College, University of Oxford
2008 - 2011 : Postdoctoral Research Assistant, Mathematical Institute, University of Oxford
2005 - 2010 : DPhil, Mathematical Institute, University of Oxford

Research interests:

I develop and apply mathematical models to study complex biological systems. Techniques range from discrete and continuous models of temporal dynamics to more computationally intensive individual-based and multiscale simulations. Major applications include mechanisms underlying tissue homeostasis and their disruption in cancer formation and progression, and the orchestration of cell-level processes such as proliferation, death, adhesion and migration to give correct tissue-level proportions in embryos.