## MAS6003 Linear Modelling

Both semesters, 2019/20 | 20 Credits | ||||

Lecturer: | Prof Richard Wilkinson | uses MOLE | Timetable | Reading List | |

Aims | Outcomes | Teaching Methods | Assessment |

The unit develops students' understanding of the general theory of linear models for regression modelling and analysing experiments, and introduces extensions to these models. Many important applications are considered, including the modelling of binary and count data, and the analysis of contingency tables and structured data. Discussion in the unit covers regression model building and model checking, multiple regression, generalised linear models, and the analysis of complete factorial experiments. It then considers mixed effects models, which are useful when the data are structured, with different levels of variation. Finally, data structures with missing parts (known as missing data) are considered in detail and relevant methods are studied.

There are no prerequisites for this module.

No other modules have this module as a prerequisite.

## Outline syllabus

- Semester 1: Linear and Generalised Linear Models
- Review of Linear Regression: Simple and multiple linear regression, linear model in matrix form, LS estimators and its distributions.
- General hypothesis testing: Distribution of LS estimators, confidence intervals, the general hypothesis testing, ANOVA tables.
- Transformations and variable selection: Variance stabilization transformations, Box-Cox transformations, variable selection, automated methods for variable selection.
- Introduction to generalized linear models: Introduction, definition, GLM distributions.
- GLM estimation: Parameter estimation, use of deviance in GLMs to test model fit. Model building (analysis of deviance), types of residuals, quasi likelihood.
- Binary response: Likelihood, links, examples, odds ratio, logistic regression.
- Poisson regression: Poisson regression for count data, using offsets to adjust for exposure.
- Two way contingency tables: Response & controlled variables, association and homogeneity, probability distributions for two-way tables.

- Semester 2: Extended Linear Models
- Review of Linear Models
- Mixed Effects Models

Mixed Effects models and REML estimation. Motivating example for mixed effects models, illustrating the classical approach for estimating variance components. Fitting a mixed effects model in R. Further examples: multilevel models (split plots and nested arrangements). - Repeated measures and the bootstrap

Further examples: repeated measures. Checking model assumptions. Comparing random effects structures with the GLRT. Bootstrapping for comparing fixed effects structures. - Missing data

Mechanisms for missing data (missing at random, missing completely at random etc.). Naive methods (i.e. analysing complete cases only). Exact missing data methods for linear models. - The EM algorithm

Introduction, structure and implementation of the EM algorithm for missing data. - Imputation method

Single imputation methods. Estimation of single imputation uncertainty. Multiple imputation methods.

## Aims

- To review and extend the student's knowledge of the standard linear model.
- To introduce the more general ideas of Mixed Effects Models and Generalized Linear Models (GLM) by building on the familiar concepts of the linear model.
- To develop enough of the theory to allow a proper understanding of what these methods can achieve.
- To show how these methods are applied to data, and what kinds of conclusion are possible.

## Learning outcomes

- understand the basic concepts.
- carry out straightforward regression analysis.
- derive minor extensions and applications of the general theory.
- carry out logistic regression and log-linear analysis of contingency tables.
- assess the fit of a model to data, and make suggestions as to how to improve it if it is unsatisfactory.
- understand basic techniques of mixed effects modelling.

## Teaching methods

Lectures, with a complete set of printed notes, plus task and exercise sheets and 4 computer classes in semester 2.

36 lectures, no tutorials, 4 practicals

## Assessment

Three hour restricted open book examination (100%). Exam format: 5 questions from 6.

## Reading list

Type | Author(s) | Title | Library | Blackwells | Amazon |
---|---|---|---|---|---|

A |
Dobson, A.J. | An Introduction to Generalized Linear Models | |||

B |
Christensen, R. | Log-linear models and Logistic Regression | |||

C |
Atkinson, A.C. | Plots, Transformations and Regression | |||

C |
Cook, R.D. \& Weisberg, S. | Residuals and Influence in Regression | |||

C |
Draper, N. and Smith, H. | Applied Regression Analysis | |||

C |
McCullagh, P J and Nelder, J A | Generalised Linear Models | |||

C |
Montgomery, D.C. and Peck, E.A. | Introduction to Linear Regression Analysis | |||

C |
Pinheiro, J.C. and Bates, D.M. | Mixed-Effects Models in S and S-Plus | |||

C |
Seber, G.A.F. | Linear Regression Analysis |

(

**A**= essential,

**B**= recommended,

**C**= background.)

Most books on reading lists should also be available from the Blackwells shop at Jessop West.

## Timetable (semester 2)

Mon | 09:00 - 09:50 | lecture | Hicks Lecture Theatre E | ||||

Tue | 14:00 - 14:50 | lecture | Hicks Lecture Theatre C |